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M94A2611.TXT
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1994-10-25
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Document 2611
DOCN M94A2611
TI High cumulative incidence of genital herpes amongst HIV-1 seropositive
heterosexuals in south London.
DT 9412
AU O'Farrell N; Tovey SJ; Lloyd Clinic, Guy's Hospital, London, UK.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):265 (abstract no. PB0488). Unique
Identifier : AIDSLINE ICA10/94369964
AB OBJECTIVE: To determine the cumulative incidence of sexually transmitted
diseases (STD) amongst a cohort of HIV-1 seropositive heterosexuals in
South London, England. METHODS: Retrospective review of case notes in 51
(35 female, 16 male) HIV-1 positive subjects attending an STD clinic who
had acquired HIV-1 infection via heterosexual transmission to August
1993. RESULTS: Thirty one (88%) of the women and 13 (81%) of the men
were of sub Saharan African origin. Approximately half of the subjects
were first diagnosed as HIV-1 positive with CD4 counts < 200 x 10(6)/1
and a quarter with CD4 counts < 50 x 10(6)/1. STD detected in women
were: genital herpes 15 (43%), candida 12 (34%), bacterial vaginosis 9
(25%), and in men: genital herpes 6 (38%, non-gonococcal urethritis 4
(25%). No cases of gonorrhoea were detected. At the time of first
diagnosis of genital herpes at the clinic, the mean CD4 count in women
was 275 x 10(6)/1 and in men 285 x 10(6)/1. Genital herpes was the AIDS
defining diagnosis in three of the women. CONCLUSIONS: The recognised
risk of HIV transmission via genital lesions should be stressed in HIV-1
positive subjects with genital herpes. The incidence of other STD was
very low--both knowledge of HIV status and safer sex counselling may
limit riskful sexual behaviour and should be evaluated further as a
strategy for limiting the spread of HIV-1 infection.
DE Cross-Sectional Studies Female Herpes
Genitalis/COMPLICATIONS/*EPIDEMIOLOGY/TRANSMISSION Human HIV
Seropositivity/COMPLICATIONS/*EPIDEMIOLOGY/TRANSMISSION *HIV-1
Incidence London/EPIDEMIOLOGY Male Risk Factors Sex Behavior Urban
Population/*STATISTICS & NUMER DATA MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).